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Anti-CD49e, Recombinant [SNAKA51]

Invented at University of Manchester, Absolute Antibody

Info

Catalogue Number 153367
Applications IF Fn WB
Antigen/Gene or Protein Targets Integrin alpha5 (CD49e)
Synonyms Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A
Reactivity Human
Relevance CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Host Mouse
Immunogen Whole cells corresponding to human Integrin alpha5.
Subclass IgG2a kappa
Formulation PBS
Concentration 1mg/ml
Research Area Adhesion, Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology
Notes Activity Assay: A representative lot of the original monoclonal antibody has been shown to convert alpha5 beta1 integrin into a ligand competant form and promotes fibronectin binding.
Immunocytochemistry Analysis: A representative lot of the original monoclonal antibody has been shown to detected Integin alpha 5 in Primary human foreskin fibroblasts (hFF)
Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

References

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References: 1 entry

Original hybridoma first published in: Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.


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References: 1 entry

Original hybridoma first published in: Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.


Add a reference

Inventor Information