Anti-CD49e, Recombinant [SNAKA51]
Invented at University of Manchester
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 153367 |
| Applications | IF Fn WB |
| Antigen/Gene or Protein Targets | Integrin alpha5 (CD49e) |
| Synonyms | Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A |
| Reactivity | Human |
| Relevance | CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. |
| Host | Mouse |
| Immunogen | Whole cells corresponding to human Integrin alpha5. |
| Subclass | IgG2a kappa |
| Formulation | PBS |
| Concentration | 1mg/ml |
| Research Area | Adhesion, Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology |
| Notes |
Activity Assay: A representative lot of the original monoclonal antibody has been shown to convert alpha5 beta1 integrin into a ligand competant form and promotes fibronectin binding. Immunocytochemistry Analysis: A representative lot of the original monoclonal antibody has been shown to detected Integin alpha 5 in Primary human foreskin fibroblasts (hFF) Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. |
References: 1 entry
Original hybridoma first published in: Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.
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References: 1 entry
Original hybridoma first published in: Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.
Add a reference
