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Anti-CD49b, Recombinant [16B4]

Info

Catalogue Number 153366
Applications ELISA FACS IHC IF IP
Antigen/Gene or Protein Targets CD49f (Integrin a2+b1)
Synonyms Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor; Alpha-2 Subunit; Human Platelet Alloantigen System; Platelet Glycoprotein GPIa; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Reactivity Human
Relevance CD49b is an integrin alpha subunit which makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
Host Mouse
Immunogen Purified human beta 1 preparation from HT1080 fibrosarcoma cell extract.
Subclass IgG1
Formulation PBS
Concentration 1mg/ml
Research Area Adhesion, Cell Signaling & Signal Transduction, Immunology
Notes 16B4 can be used to immunoprecipitate a non-reducible alpha subunit from I(125) surface labelled Human cell line extract. It is specific to the alpha 2 subunit by relative expression of antigen on various cell lines by FACS, and its recognition of affinity purified alpha 2 beta 1 in dot blots.
Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

References

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References: 1 entry

Original hybridoma first published in: Fitter et al. 1999. Biochem J. 338 ( Pt 1):61-70. PMID: 9931299.


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References: 1 entry

Original hybridoma first published in: Fitter et al. 1999. Biochem J. 338 ( Pt 1):61-70. PMID: 9931299.


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