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Anti-IgNAR [V39]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 153311
Applications ELISA WB
Antigen/Gene or Protein Targets IgNAR immunoglobulin heavy chain membrane and secretory forms
Synonyms Small-spotted catshark IgNAR, IgNAR antibody, Nanobody, Single domain antibody
Reactivity Small-spotted catshark
Relevance Sharks, and other members in Chondrichthyes, produce, apart from the expected IgM and IgW, a type of ancestral antibody referred to immunoglobulin new antigen receptor (IgNAR). IgNAR antibody is composed of only a homodimeric heavy chain which contains one variable and five constant domains for each chain. The distinct structure of IgNAR domains leads to extremely high stability. In addition, VNAR is around 10 times smaller than standard antibodies and able to continue to function and exist within very extreme conditions. These properties allow IgNAR to penetrate tissues easier in vivo to improve bioavailability for pharmaceutical applications. Anti-IgNAR antibody (V39) can be used to monitor IgNAR levels in shark following immunization
Host Mouse
Immunogen Ovalbumin-conjugated short synthetic peptide
Positive Control Western Blot, sera
Subclass IgG1
Myeloma Used P3X63Ag8.653
Strain Balb/c
Research Area Aquaculture

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