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SDHB Floxed Mouse

Info

Catalogue Number 153295
Antigen/Gene or Protein Targets Succinate dehydrogenase
Disease Keywords Cancer
Synonyms Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
Model Transgenic
Relevance Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
Conditional Description Exon 3 of the succinate dehydrogenase can be deleted upon Cre recombinase expression as this exon is flanked with lox P sequences
Strain C57BL/6
Mouse Genetic Background/Cross History Backcrossed 10 times into C57/BL6
Zygosity Homozygous
Research Area Cancer, Drug Discovery & Development, Genetic Studies Tools, Metabolism

References

There are 2 reference entries for this reagent.

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References: 2 entries

Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

Europe PMC ID: 26302408


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References: 2 entries

Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.


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