SDHB Floxed Mouse
Invented at Cancer Research UK Glasgow: The Beatson Institute
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153295 |
| Antigen/Gene or Protein Targets | Succinate dehydrogenase |
| Disease Keywords | Cancer |
| Synonyms | Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR |
| Model | Transgenic |
| Relevance | Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation. |
| Conditional Description | Exon 3 of the succinate dehydrogenase can be deleted upon Cre recombinase expression as this exon is flanked with lox P sequences |
| Strain | C57BL/6 |
| Mouse Genetic Background/Cross History | Backcrossed 10 times into C57/BL6 |
| Zygosity | Homozygous |
| Research Area | Cancer, Drug Discovery & Development, Genetic Studies Tools, Metabolism |
References: 2 entries
Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Europe PMC ID: 26302408
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References: 2 entries
Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Add a reference
