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Sdhb fl/fl Cell Line

Info

Catalogue Number 153294
Antigen/Gene or Protein Targets Succinate dehydrogenase
Synonyms Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
Host Mouse
Tissue Kidney
Disease Keywords Cancer
Model Conditional KO
Relevance Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
Conditional Yes
Conditional Description Deletion of succinate dehydrogenase can be achieved by intracellular expression of Cre recombinase
Research Area Cancer, Drug Discovery & Development, Metabolism
Cellosaurus ID CVCL_HG11

References

There are 2 reference entries for this reagent.

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References: 2 entries

Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

Europe PMC ID: 26302408


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References: 2 entries

Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.


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