Cancer Research Technology
Log in Register
Menu

FH-/- CL 19 Cell Line

Info

Catalogue Number 153290
Antigen/Gene or Protein Targets Fumarate Hydratase
Synonyms Fumarate hydratase, FH, fumarase, Fh1, Hereditary leiomyomatosis and renal cell cancer, HLRCC
Host Mouse
Tissue Kidney
Disease Keywords Cancer
Model Knock-Out
Relevance Fumarate hydratase – which can be found in either a mitochondrial or cytosolic form - is an enzyme that catalyzes the reversible hydration and dehydration of fumarate to malate. Signal sequences located in the protein dictate the subcellular location of each FH isoenzyme. The cytosolic form is involved in the metabolism of amino acids and fumarate and the mitochondrial form is involved in the Krebs Cycle (tricarboxylic acid cycle or the citric acid cycle). Germline mutations of FH are responsible for hereditary leiomyomatosis and renal-cell cancer (HLRCC)1.
Research Area Cancer, Drug Discovery & Development, Metabolism
Cellosaurus ID CVCL_HG02

References

There are 4 reference entries for this reagent.

View All References

References: 4 entries

Frezza et al. 2011. Nature. 477(7363):225-8. PMID: 21849978.

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

Europe PMC ID: 21849978

Pollard et al. 2007. Cancer Cell. 11(4):311-9. PMID: 17418408.

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.

Europe PMC ID: 17418408


Add a reference

References: 4 entries

Frezza et al. 2011. Nature. 477(7363):225-8. PMID: 21849978.

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

Pollard et al. 2007. Cancer Cell. 11(4):311-9. PMID: 17418408.

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.


Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor