phOC-iNOS Vector
RECENTLY UPDATED
RECENTLY UPDATED
Invented by Dr Helen McCarthy from Queen's University Belfast
Invented at Queen's University Belfast
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153288 |
| Bacterial Resistance | Kanamycin |
| Vector Type | pcDNA 3.1 |
| Synonyms | Nitric Oxide Synthase |
| Antigen/Gene or Protein Targets | Inducible Nitric Oxide Synthase |
| Relevance |
phOC-iNOS Plasmid is a human nitric oxide synthase (iNOS) transgene driven by a human osteocalcin (hOC) promoter to control inducible nitric oxide synthase (iNOS) transgene expression in hormone refractory prostate cancer (HRPC). The plasmid was originally developed as an anti-cancer therapeutic with a view to a gene therapy strategies. Studies in the literature have demonstrated that this plasmid increases iNOS protein and total nitrite levels in PC3 and DU145 cells, but not LNCaP or HT29 (McCarthy et al., 2007). The plasmid serves as a useful tool in cardiovascular studies or any physiology associated with vasodilation. |
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Research Area
RECENTLY UPDATED |
Cancer, Metabolism, Neurobiology |
| Notes |
Recommended for transpormation in DH5 alpha bacterial cells iNOS gene is 4.4kb |
References: 2 entries
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RECENTLY UPDATED
McCarthy et al. 2007. J Gene Med. 9(6):511-20. PMID: 17471586.
Human osteocalcin: a strong promoter for nitric oxide synthase gene therapy, with specificity for hormone refractory prostate cancer.
Europe PMC ID: 17471586
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References: 2 entries
RECENTLY UPDATED
RECENTLY UPDATED
McCarthy et al. 2007. J Gene Med. 9(6):511-20. PMID: 17471586.
Human osteocalcin: a strong promoter for nitric oxide synthase gene therapy, with specificity for hormone refractory prostate cancer.
Add a reference
