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Anti-sCD40 (soluble), Recombinant [T8P2G4*A6]

Info

Catalogue Number 153286
Applications ELISA IHC WB
Antigen/Gene or Protein Targets CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40 soluble form)
Synonyms CD40 Molecule; CD40L Receptor; TNFRSF5; CDW40; Bp50; Tumor Necrosis Factor Receptor Superfamily; Member; B Cell Surface Antigen CD40; CD40 Antigen; P50
Reactivity Human
Relevance CD40 is a 48 kD type I glycoprotein and a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide RDPVCHPLGA (C-terminal sequence)
Subclass IgG1 kappa
Formulation PBS
Concentration 1mgml-1
Positive Control IHC - formalin-fixed, paraffin-embedded hepatocellular carcinoma sections; WB - Jurkat cell lysates
Research Area Cancer, Immunology
Notes Recombinant monoclonal antibody produced from the original monoclonal cell line. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

Five products available based on this clone:
- Anti-sCD40 [T8P2G4*A6], Mouse IgG1, Kappa
- Anti-sCD40 [T8P2G4*A6], Rabbit IgG, Kappa
- Anti-sCD40 [T8P2G4*A6], Human IgG4-S228P, Kappa
- Anti-sCD40 [T8P2G4*A6], Human IgG1, Kappa
- Anti-sCD40 [T8P2G4*A6], Human IgG1, Kappa, engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors

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