Anti-BORIS, Recombinant [20B11]
Invented by Prof Elena Klenova from University of Essex
Invented at University of Essex
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 153257 |
| Applications | ChIP ELISA IHC IF IP WB |
| Antigen/Gene or Protein Targets | BORIS |
| Synonyms | Brother of the regulator of imprinted sites, Cancer/testis antigen 27, CCCTC binding factor (zinc finger protein) like, CCCTC-binding factor, CT27, CTCF paralog, CTCF T, CTCF-like protein, Ctcfl, CTCFL_HUMAN, dJ579F20.2, HMG 1L1, HMGB1L1, MGC163358, MGC169105, MGC169106 |
| Reactivity | Human |
| Relevance | Reagent for research, diagnostic tool. BORIS protein has been identified as Cancer-Testis Antigen (CTA) with testis-specific paralogue of the CCCTC-binding factor. Recent studies have demonstrated that d BORIS is directly responsible for the transcriptional activation of TSP50 (testes-specific protease 50). |
| Host | Mouse |
| Immunogen | Synthetic peptide within the BORIS C-terminal domain (aa 614-648) (CG)GEMFPVACRETTARVKEE (NB - the first two aa do not belong to BORIS) |
| Subclass | IgG3 kappa |
| Formulation | PBS |
| Concentration | 1mgml-1 |
| Positive Control | MCF7 cell lysates |
| Research Area | Cancer, Epigenetics & Nuclear Signalling |
| Notes |
Recombinant monoclonal antibody produced from the original monoclonal cell line. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. Five products based on this clone: - Anti-BORIS [20B11], Mouse IgG3, Kappa - Anti-BORIS [20B11], Rabbit IgG, Kappa - Anti-BORIS [20B11], Human IgG1, Kappa - Anti-BORIS [20B11], Human IgG1, Kappa, engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors - Anti-BORIS [20B11], Human IgG4-S228P, Kappa |
