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Anti-CD18 [BU87]

Invented by Dr Margaret Goodall at University Of Birmingham

Info

Catalogue Number 153231
Applications IHC
Antigen/Gene or Protein Targets CD18
Synonyms Cell differentiation 18; Integrin beta-2; ITGB2 gene
Reactivity Human, Pig and Primate
Relevance The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form and these ligand binding proteins are inversely associated with disease activity in the autoimmune disease spondyloarthritis.
Host Mouse
Subclass IgG2a
Strain Balb/c
Research Area Adhesion, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References

There are 3 reference entries for this reagent.

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References: 3 entries

Leucocyte Typing VI, 1998, Kishimoto_T. Garland Publishing, NY.

Carter et al. 1999. Xenotransplantation. 6(2):123-30. PMID: 10431789.

Cross-species reactivity of a panel of antibodies with monkey and porcine tissue.

Europe PMC ID: 10431789


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References: 3 entries

Leucocyte Typing VI, 1998, Kishimoto_T. Garland Publishing, NY.

Carter et al. 1999. Xenotransplantation. 6(2):123-30. PMID: 10431789.

Cross-species reactivity of a panel of antibodies with monkey and porcine tissue.


Add a reference