Anti-CD18 [BU86]
Invented by Dr Margaret Goodall from University Of Birmingham
Invented at University Of Birmingham
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 153230 |
| Applications | FACS IHC |
| Antigen/Gene or Protein Targets | CD18 |
| Synonyms | Cell differentiation 18; Integrin beta-2; ITGB2 gene |
| Reactivity | Human |
| Relevance | The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form and these ligand binding proteins are inversely associated with disease activity in the autoimmune disease spondyloarthritis. |
| Host | Mouse |
| Subclass | IgG1 |
| Strain | Balb/c |
| Research Area | Adhesion, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology |
