Anti-CD21 [BU80]
Invented by Dr Margaret Goodall from University Of Birmingham
Invented at University Of Birmingham
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 153223 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | CD21 |
| Synonyms | Complement receptor type 2; CR2; complement C3d receptor, C3DR, Epstein-Barr virus receptor |
| Reactivity | Human |
| Relevance |
Cluster of differentiation 21 (CD21) is a protein encoded by the CR2 gene in humans. It is involved in the complement system and binds to iC3b (an inactive derivative of C3b). B cells are known to have CR2 receptors on their surfaces allowing the complement system to act in B-cell maturation and activation. Genetic variations are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) which is a chronic autoimmune disease with an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. |
| Host | Mouse |
| Immunogen | Daudi cell line (B lymphoblast) |
| Subclass | IgG1 |
| Strain | Balb/c |
| Research Area | Immunology |
References: 3 entries
Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.
Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.
Leucocyte Typing VI, (1998): edited by T. Kishimoto, Garland Publishing, New York.
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References: 3 entries
Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.
Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.
Leucocyte Typing VI, (1998): edited by T. Kishimoto, Garland Publishing, New York.
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