Anti-CD74 [BU45]
Invented by Dr Margaret Goodall from University Of Birmingham
Invented at University Of Birmingham
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 153218 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | CD74 |
| Synonyms | HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Cluster of Differentiation 74 |
| Reactivity | Human |
| Relevance | CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short lasting only 3 to 4 min, before internalization. It has been suggested that CD74 on the cell surface binds MHC class II molecules which have lost their antigenic peptide promoting internalization and reloading with antigenic peptide. |
| Host | Mouse |
| Immunogen | B lymphoblastoid cell line: HFB1 |
| Subclass | IgG1 |
| Strain | Balb/c |
| Research Area | Immunology |
References: 4 entries
Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.
Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.
Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.
Human major histocompatibility complex class II invariant chain is expressed on the cell surface.
Europe PMC ID: 1690714
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References: 4 entries
Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.
Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.
Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.
Human major histocompatibility complex class II invariant chain is expressed on the cell surface.
Add a reference
