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Anti-CD74 [BU45]

Invented by Dr Margaret Goodall at University Of Birmingham

Info

Catalogue Number 153218
Applications IHC
Antigen/Gene or Protein Targets CD74
Synonyms HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Cluster of Differentiation 74
Reactivity Human
Relevance CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short lasting only 3 to 4 min, before internalization. It has been suggested that CD74 on the cell surface binds MHC class II molecules which have lost their antigenic peptide promoting internalization and reloading with antigenic peptide.
Host Mouse
Immunogen B lymphoblastoid cell line: HFB1
Subclass IgG1
Strain Balb/c
Research Area Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.

Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.

Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.

Human major histocompatibility complex class II invariant chain is expressed on the cell surface.

Europe PMC ID: 1690714


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References: 4 entries

Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.

Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.

Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.

Human major histocompatibility complex class II invariant chain is expressed on the cell surface.


Add a reference