Anti-Phospho Endosulfine [DF1.1]
Invented by Julian Gannon from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
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![Image thumbnail for Anti-Phospho Endosulfine [DF1.1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/bac151cd-f0f7-4b49-a452-f54d283a81e8.jpg)
| Catalogue Number | 153180 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Phospho Endosulfine |
| Reactivity | Xenopus laevis |
| Relevance |
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. Endosulfine is highly phosphorylated in Xenopus CSF egg extracts but de-phosphorylated when the eggs enter interphase. |
| Host | Mouse |
| Immunogen | Synthetic peptide - KGQKYFD-Sp-GDYNMAK |
| Positive Control | Xenopus CSF (cytostatic factor extract) |
| Molecular Weight (kDa) | 14 |
| Notes |
Raised from mice immunized with amino acids 60-74 from Xenopus and Human endosulfine where amino acid 67 is phospho-serine: Human [KGQKYFD-Sp-GDYNMAK] (Ser 67) Reacts against Xenopus Phospho Endosulfine. Not tested against human and mouse. |
| Research Area | Neurobiology |
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