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Monoclonal Antibodies

Anti-SMC3 [DJ5.2.3]

Invented by Julian Gannon from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
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Figure. Immoblots using Anti-Acetyl SMC3 [EN9.1] and Anti-SMC3 [DJ5.2.3]. DJ5.2.3 immunoblots all forms of SMC3 while EN9.1 immunoblots only the Acetyl SMC3.
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Image thumbnail for Anti-SMC3 [DJ5.2.3]
Catalogue Number 153176
Applications WB
Antigen/Gene or Protein Targets SMC3
Reactivity Xenopus laevis, Human and Mouse
Relevance SMC3 is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.
Host Mouse
Immunogen Synthetic peptide - EEVSLRRVIGAKacetyl Kacetyl DQYFLDKK
Positive Control Xenopus chromatin extract
Molecular Weight (kDa) 141
Notes Raised from mice immunized with the peptide sequence:
EEVSLRRVIGAKKDQYFLDKK
corrosponding to amino acids 94 -114 of Xenopus laevis SMC3

DJ5.2.3 reacts against SMC3 from Xenopus, human and mouse.
Research Area Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

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