Anti-S100A12, Polyclonal [NH4]
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153163 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | S100A12 |
| Synonyms | MRP-6, calgranulin C, ENRAGE |
| Reactivity | Human |
| Relevance | Major biomarker of inflammation eg. inflammatory bowel disease, rheumatoid arthritis. Serves a ligand for RAGE (receptor for advanced glycation products) with role in tumour growth and wound healing. |
| Host | Rabbit |
| Immunogen | Recombinant human S100A12 |
| Formulation | Whole serum |
| Molecular Weight (kDa) | 6 |
| Notes |
Western blotting, 1:50,000; Immunoprecipitation, 2-3 ug; Immunohistology (paraffin, 1:2000; acetone, 1:500) Application dilutions are based on using crude serum. Staining pattern (sub-cellular localisation of antibody): cytosolic protein (5% protein in neutrophils); some co-distribution with S100A8/A9 but more restricted epithelial staining. |
| Positive Control | Human neutrophils |
| Research Area | Cell Signaling & Signal Transduction, Immunology |
References: 2 entries
Robinson et al. 2000. Biochem Biophys Res Commun. 275(3):865-70. PMID: 10973813.
A comparison of human S100A12 with MRP-14 (S100A9).
Europe PMC ID: 10973813
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References: 2 entries
Robinson et al. 2000. Biochem Biophys Res Commun. 275(3):865-70. PMID: 10973813.
A comparison of human S100A12 with MRP-14 (S100A9).
Add a reference
