Cancer Research Technology
Log in Register
Menu

Anti-PIAS2, Polyclonal [PIAS2]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets PIAS2
Reactivity Human and Mouse
Relevance Functions as an E3­type small ubiquitin­like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO­tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO­mediated repression of ELK1 transactivation activity. Isoform PIAS2­beta, but not isoform PIAS2­alpha, promotes MDM2 sumoylation. Isoform PIAS2­alpha promotes PARK7 sumoylation. Isoform PIAS2­beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2­alpha
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 68.2  
Research Area Epigenetics & Nuclear Signalling

References

There are 0 reference entries for this reagent.

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor