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Anti-DPF1, Polyclonal [DPF1]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets DPF1
Reactivity Human and Mouse
Relevance May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuronspecific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post­mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post­mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron­specific complexes (nBAF). The npBAF complex is essential for the self­renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.  
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 46.8, 42.5 & 37.9  
Research Area Epigenetics & Nuclear Signalling, Neurobiology

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