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Anti-GFAP [FD19-9]

Invented by Dr JOHN KEMSHEAD at SHIRE PHARMACEUTICALS

Info

Catalogue Number 152989
Applications IHC IF
Antigen/Gene or Protein Targets Glial fibrillary acid protein
Synonyms wu:fb34h11, ALXDRD, cb345, etID36982.3, FLJ42474, FLJ45472, GFAP, GFAP_HUMAN, gfapl, Glial fibrillary acidic protein, Intermediate filament protein, wu:fk42c12, xx:af506734, zgc:110485
Reactivity Human
Relevance Glial fibrillary acidic protein, or GFAP, is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demylination diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system.
Host Mouse
Immunogen Relatively benign cerebellar astrocytoma from 5 year old child.
Positive Control HeLa whole cell lysate
Subclass IgG1
Molecular Weight (kDa) 50
Myeloma Used P3X63Ag8
Strain Balb/c
Research Area Adhesion, Cell Signaling & Signal Transduction, Neurobiology, Stem Cell Biology

References

There are 7 reference entries for this reagent.

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References: 7 entries

Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461.

Isolation and characterization of human gastric cell lines with stem cell phenotypes.

Europe PMC ID: 17645461

Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008.

High efficiency transfection of glioma cell lines and primary cells for overexpression and RNAi experiments.

Europe PMC ID: 16621008

Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.

IHC

Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.

Europe PMC ID: 6202990

Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983


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References: 7 entries

Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461.

Isolation and characterization of human gastric cell lines with stem cell phenotypes.

Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008.

High efficiency transfection of glioma cell lines and primary cells for overexpression and RNAi experiments.

Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.

IHC

Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.

Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983


Add a reference