Anti-GFAP [FD19-9]
Invented by Dr JOHN KEMSHEAD from SHIRE PHARMACEUTICALS
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (7)
- Inventor Info
Info
| Catalogue Number | 152989 |
| Applications | IHC IF |
| Antigen/Gene or Protein Targets | Glial fibrillary acid protein |
| Synonyms | wu:fb34h11, ALXDRD, cb345, etID36982.3, FLJ42474, FLJ45472, GFAP, GFAP_HUMAN, gfapl, Glial fibrillary acidic protein, Intermediate filament protein, wu:fk42c12, xx:af506734, zgc:110485 |
| Reactivity | Human |
| Relevance | Glial fibrillary acidic protein, or GFAP, is an intermediate filament (IF) protein belonging to the type III subclass of IF proteins. Like other IF proteins, GFAP is composed of an amino terminal head domain, central rod domain and a carboxy terminal tail domain. GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demylination diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system. |
| Host | Mouse |
| Immunogen | Relatively benign cerebellar astrocytoma from 5 year old child. |
| Positive Control | HeLa whole cell lysate |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 50 |
| Myeloma Used | P3X63Ag8 |
| Strain | Balb/c |
| Research Area | Adhesion, Cell Signaling & Signal Transduction, Neurobiology, Stem Cell Biology |
References: 7 entries
Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461.
Isolation and characterization of human gastric cell lines with stem cell phenotypes.
Europe PMC ID: 17645461
Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008.
High efficiency transfection of glioma cell lines and primary cells for overexpression and RNAi experiments.
Europe PMC ID: 16621008
Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.
IHC
Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.
Europe PMC ID: 6202990
Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983
Add a reference
References: 7 entries
Yang et al. 2007. J Gastroenterol Hepatol. 22(9):1460-8. PMID: 17645461.
Isolation and characterization of human gastric cell lines with stem cell phenotypes.
Hagemann et al. 2006. J Neurosci Methods. 156(1-2):194-202. PMID: 16621008.
High efficiency transfection of glioma cell lines and primary cells for overexpression and RNAi experiments.
Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.
IHC
Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.
Garson JA. The development and characterisation of monoclonal antibodies for use in neuropathology. MD thesis. University of Birmingham, 1983
Add a reference
