Anti-NEUROD2, Polyclonal [NEUROD2]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | NEUROD2 |
| Reactivity | Human and Mouse |
| Relevance | Transcriptional regulator implicated in neuronal determination. Mediates calciumdependent transcription activation by binding to E boxcontaining promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by downregulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamicpituitary axis. Associates with chromatin to the DPYSL3 E boxcontaining promoter |
| Host | Rabbit |
| Immunogen | 3 synthetic peptides (human) conjugated to KLH |
| Molecular Weight (kDa) | 41.3 |
| Research Area | Epigenetics & Nuclear Signalling, Neurobiology, Stem Cell Biology |
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