Anti-STAT5A, Polyclonal [STAT5A]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | STAT5A |
| Reactivity | Human and Mouse |
| Relevance | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GMCSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCLX(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq] |
| Host | Rabbit |
| Immunogen | 3 synthetic peptides (human) conjugated to KLH |
| Molecular Weight (kDa) | 90.59999999999999 |
| Research Area | Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling |
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