Cancer Research Technology
Log in Register
Menu

Anti-CD11b [2LPM19c]

Invented by Karen Pulford at University of Oxford

Info

Catalogue Number 152935
Applications FACS IHC
Antigen/Gene or Protein Targets Cluster of Differentiation 11b (CD11b)
Synonyms CD11b, Integrin alpha M, Integrin aM, Mac-1 a subunit, C3bi receptor, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor
Reactivity Human
Relevance CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies.

CD11b is part of the CD11b/CD18 heterodimer (Mac-1 a, Mß2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain.
Host Mouse
Immunogen Purified C3bi receptor
Subclass IgG1 kappa
Molecular Weight (kDa) 127
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + glutamine (2mM) + HAT
Research Area Adhesion, Apoptosis and Programmed Cell Death, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Neurobiology, Stem Cell Biology

References

There are 6 reference entries for this reagent.

View All References

References: 6 entries

Kupatt et al. 2000. Arterioscler Thromb Vasc Biol. 20(10):2226-32. PMID: 11031208.

c7E3Fab reduces postischemic leukocyte-thrombocyte interaction mediated by fibrinogen. Implications for myocardial reperfusion injury.

Europe PMC ID: 11031208

Violette et al. 1995. J Immunol. 155(6):3092-101. PMID: 7673724.

Differences in the binding of blocking anti-CD11b monoclonal antibodies to the A-domain of CD11b.

Europe PMC ID: 7673724

Diamond et al. 1993. J Cell Biol. 120(4):1031-43. PMID: 7679388.

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

Europe PMC ID: 7679388


Add a reference

References: 6 entries

Kupatt et al. 2000. Arterioscler Thromb Vasc Biol. 20(10):2226-32. PMID: 11031208.

c7E3Fab reduces postischemic leukocyte-thrombocyte interaction mediated by fibrinogen. Implications for myocardial reperfusion injury.

Violette et al. 1995. J Immunol. 155(6):3092-101. PMID: 7673724.

Differences in the binding of blocking anti-CD11b monoclonal antibodies to the A-domain of CD11b.

Diamond et al. 1993. J Cell Biol. 120(4):1031-43. PMID: 7679388.

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.


Add a reference