Anti-XPA [2A4]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 152930 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | XPA |
| Synonyms | DNA repair protein complementing XP A cells, DNA repair protein complementing XP-A cells, DNA repair protein complementing XPA cells, Excision repair controlling, Xeroderma pigmentosum 1, Xeroderma pigmentosum complementation group A, Xeroderma pigmentosum group A complementing protein, Xeroderma pigmentosum group A-complementing protein, XP 1, XP1, xpa, Xpac |
| Reactivity | Human |
| Relevance | XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV. |
| Host | Mouse |
| Immunogen | His-tagged recombinant human XPA protein. |
| Positive Control | HeLa cell lysate |
| Subclass | IgG1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | 2A4 may be used for the nuclear staining of XPA in human cells. |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 2 entries
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
Europe PMC ID: 23209410
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
IF
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References: 2 entries
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
IF
Add a reference
