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Anti-HLA DP alpha [TAL3C3]

Info

Catalogue Number 152929
Applications IHC RIA WB
Antigen/Gene or Protein Targets HLA DP alpha (DQ to a lesser extent)
Reactivity Human
Relevance Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 3C3 may be used for tissue typing on lymphoblastoid cells, transplantation typing, disease susceptibility and detection of class II products.
Host Mouse
Immunogen Bristol 8 separated alpha chain preparation
Subclass IgG1
Molecular Weight (kDa) 33
Myeloma Used P3/NS1/1-Ag4-1
Recommended Growing Conditions RPMI 1640 + 10% FCS
Strain Balb/c
Notes TAL 3C3 is reactive on fixed tissue, reacts to class II antigens and cross-reacts with smooth muscle. Not cytotoxic with rabbit complement. TAL 3C3 detects alpha chain only by western blot and not the dimer.
Research Area Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Thomas et al. 1988. J Pathol. 154(4):353-63. PMID: 2455029.

HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle.

Europe PMC ID: 2455029

Adams et al. 1983. Immunology. 50(4):613-24. PMID: 6197354.

Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.

Europe PMC ID: 6197354


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References: 4 entries

Thomas et al. 1988. J Pathol. 154(4):353-63. PMID: 2455029.

HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle.

Adams et al. 1983. Immunology. 50(4):613-24. PMID: 6197354.

Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.


Add a reference

Inventor Information