Anti-HLA DP alpha [TAL3C3]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 152929 |
| Applications | IHC RIA WB |
| Antigen/Gene or Protein Targets | HLA DP alpha (DQ to a lesser extent) |
| Reactivity | Human |
| Relevance | Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 3C3 may be used for tissue typing on lymphoblastoid cells, transplantation typing, disease susceptibility and detection of class II products. |
| Host | Mouse |
| Immunogen | Bristol 8 separated alpha chain preparation |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 33 |
| Myeloma Used | P3/NS1/1-Ag4-1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS |
| Strain | Balb/c |
| Notes | TAL 3C3 is reactive on fixed tissue, reacts to class II antigens and cross-reacts with smooth muscle. Not cytotoxic with rabbit complement. TAL 3C3 detects alpha chain only by western blot and not the dimer. |
| Research Area | Immunology |
References: 4 entries
Thomas et al. 1988. J Pathol. 154(4):353-63. PMID: 2455029.
HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle.
Europe PMC ID: 2455029
Adams et al. 1983. Immunology. 50(4):613-24. PMID: 6197354.
Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.
Europe PMC ID: 6197354
Add a reference
References: 4 entries
Thomas et al. 1988. J Pathol. 154(4):353-63. PMID: 2455029.
HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle.
Adams et al. 1983. Immunology. 50(4):613-24. PMID: 6197354.
Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.
Add a reference
