Anti-L1CAM [S10-33]
Invented at IFOM-IEO
- Datasheet
- References (2)
- Inventor Info
Info
| Applications | ELISA IF |
| Antigen/Gene or Protein Targets | L1 adhesion molecule |
| Reactivity | Mouse |
| Relevance |
Monoclonal antibody specific to L1CAM, a glycoprotein involved in various X-linked neurological syndromes. Background and Research Application L1 adhesion molecule (L1CAM) is an axonal glycoprotein belonging to the immunoglobulin supergene family. It is a transmembrane protein and a cell adhesion molecule with an important role in the development of the nervous system, including neuronal migration, and differentiation. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Cancer cells can proteolytically cleave NCAM-L1, releasing the soluble ectodomain. |
| Host | Rat |
| Immunogen UniProt ID | P11627 |
| Myeloma Used | Sp2/0 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Adhesion, Cell Signaling & Signal Transduction, Neurobiology |
References: 2 entries
Maddaluno et al. 2009. J Exp Med. 206(3):623-35. PMID: 19273627.
The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells.
Europe PMC ID: 19273627
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References: 2 entries
Maddaluno et al. 2009. J Exp Med. 206(3):623-35. PMID: 19273627.
The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells.
Add a reference
