Anti-Cmt2 [I3-4-14]
Invented at IFOM-IEO
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Info
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | p31 comet |
| Relevance | CMT2, KIF1B, or kinesin-like protein (Klp) functions as a motor for mitochondrial transport, and has a microtubule plus end-directed motility. The KIF1B beta isoform is abundant in brain, while the alpha isoform is abundant in skeletal muscle. Mutations in the KIF1B gene are the cause of Charcot-Marie-Tooth disease type 2A1, which is a primary peripheral axon neuropathy. The KIF1B beta isoform is down-regulated in sporadic amyotrophic lateral sclerosis (ALS). |
| Host | Mouse |
| Myeloma Used | Sp2/0 |
| Research Area | Adhesion, Cell Signaling & Signal Transduction, Cell Structure and Motility, Neurobiology |
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