Anti-USP3 [AE9-12-1]
Invented at IFOM-IEO
- Datasheet
- References (2)
- Inventor Info
Info
| Applications | IP WB |
| Antigen/Gene or Protein Targets | Ubiquitin Speciļ¬c Protease 3 |
| Synonyms | Deubiquitinating enzyme 3, EC 3.1.2.15, SIH003, Ubiquitin carboxyl-terminal hydrolase 3, Ubiquitin specific peptidase 3, Ubiquitin specific processing protease 3, Ubiquitin Specific Protease 3, Ubiquitin thioesterase 3, Ubiquitin thiolesterase 3, Ubiquitin-specific-processing protease 3, UBP, UBP3_HUMAN, Usp3 |
| Reactivity | Human and Mouse |
| Relevance | Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. |
| Host | Mouse |
| Myeloma Used | Sp2/0 |
| Research Area | Cancer, Cell Signaling & Signal Transduction, DNA Damage and Repair, Epigenetics & Nuclear Signalling, Metabolism, Protein Degradation |
References: 2 entries
Nicassio et al. 2007. Curr Biol. 17(22):1972-7. PMID: 17980597.
Human USP3 is a chromatin modifier required for S phase progression and genome stability.
Europe PMC ID: 17980597
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References: 2 entries
Nicassio et al. 2007. Curr Biol. 17(22):1972-7. PMID: 17980597.
Human USP3 is a chromatin modifier required for S phase progression and genome stability.
Add a reference
