Cancer Research Technology
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Anti-TERF1 [BED5-57-6]

Info

Applications WB
Antigen/Gene or Protein Targets NIMA interacting 1
Synonyms hTRF1 AS, NIMA interacting protein 2, NIMA-interacting protein 2, PIN 2, PIN2, t TRF1, Telomeric protein Pin2, Telomeric protein Pin2/TRF1, Telomeric repeat binding factor (NIMA interacting) 1, Telomeric repeat binding factor 1, Telomeric repeat binding protein 1
Reactivity Human, Mouse, Mouse and Rat
Relevance Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Host Mouse
Subclass IgG1 kappa
Myeloma Used Sp2/0
Research Area Cancer, Cell Type or Organelle Marker, DNA Damage and Repair, Epigenetics & Nuclear Signalling

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