Anti-NUMA1 [AD6-1]
Invented at IFOM-IEO
- Datasheet
- References (4)
- Inventor Info
Info
| Applications | IF |
| Antigen/Gene or Protein Targets | Nuclear Mitotic Apparatus Protein 1 |
| Synonyms | NMP 22, Nuclear matrix protein 22, Nuclear mitotic apparatus protein 1, Nuclear mitotic apparatus protein, NUMA 1, NUMA, NuMA protein, NUMA1, NUMA1_HUMAN, SP H antigen, SP-H antigen, Structural nuclear protein |
| Reactivity | Human |
| Relevance | Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles during symmetric cell divisions, functioning as a tether linking bulk microtubules of the spindle to centrosomes. |
| Host | Mouse |
| Myeloma Used | Sp2/0 |
| Research Area | Cell Cycle |
References: 4 entries
Carminati et al. 2016. Nat Struct Mol Biol. 23(2):155-63. PMID: 26751642.
Gallini et al. 2016. Curr Biol. 26(4):458-69. PMID: 26832443.
NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation.
Europe PMC ID: 26832443
Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation.
Europe PMC ID: 26751642
Add a reference
References: 4 entries
Carminati et al. 2016. Nat Struct Mol Biol. 23(2):155-63. PMID: 26751642.
Gallini et al. 2016. Curr Biol. 26(4):458-69. PMID: 26832443.
NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation.
Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation.
Add a reference
