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Anti-Mad2 [AS55-A12]

Info

Applications IF IP WB
Antigen/Gene or Protein Targets Mitotic Arrest Deļ¬cientl like 2
Synonyms HsMAD2, MAD 2, MAD2 like 1, MAD2 mitotic arrest deficient like 1, MAD2-like protein 1, Mad2l1, MD2L1_HUMAN, Mitotic arrest deficient 2-like protein 1, Mitotic spindle assembly checkpoint protein MAD2A, REV7
Reactivity Human
Relevance Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Host Mouse
Subclass IgG2b kappa
Myeloma Used Sp2/0
Research Area Cancer, Cell Cycle

References

There are 10 reference entries for this reagent.

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References: 10 entries

Screpanti et al. 2011. Curr Biol. 21(5):391-8. PMID: 21353556.

Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.

Europe PMC ID: 21353556

Santaguida et al. 2010. J Cell Biol. 190(1):73-87. PMID: 20624901.

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.

Europe PMC ID: 20624901

De Antoni et al. 2005. Curr Biol. 15(3):214-25. PMID: 15694304.

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.

Europe PMC ID: 15694304

Steensgaard et al. 2004. EMBO Rep. 5(6):626-31. PMID: 15133482.

Sgt1 is required for human kinetochore assembly.

Europe PMC ID: 15133482

DeLuca et al. 2003. Curr Biol. 13(23):2103-9. PMID: 14654001.

Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores.

Europe PMC ID: 14654001


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References: 10 entries

Screpanti et al. 2011. Curr Biol. 21(5):391-8. PMID: 21353556.

Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.

Santaguida et al. 2010. J Cell Biol. 190(1):73-87. PMID: 20624901.

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.

De Antoni et al. 2005. Curr Biol. 15(3):214-25. PMID: 15694304.

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.

Steensgaard et al. 2004. EMBO Rep. 5(6):626-31. PMID: 15133482.

Sgt1 is required for human kinetochore assembly.

DeLuca et al. 2003. Curr Biol. 13(23):2103-9. PMID: 14654001.

Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores.


Add a reference

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