Anti-Mad1 [BB3-8]
Invented at IFOM-IEO
- Datasheet
- References (10)
- Inventor Info
Info
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | Mitotic Arrest Deļ¬cientl like 1 |
| Synonyms | hMAD1, HsMAD1, MAD1, MAD1 mitotic arrest deficient like 1 (yeast), MAD1-like protein 1, MAD1L1, MD1L1_HUMAN, Mitotic arrest deficient 1, Mitotic arrest deficient 1-like protein 1, Mitotic checkpoint MAD1 protein homolog, Mitotic spindle assembly checkpoint protein MAD1, PIG9, Tax binding protein 181, Tax-binding protein 181, TP53I9, Tumor protein p53 inducible protein 9, TXBP181 |
| Reactivity | Human |
| Relevance | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. |
| Host | Mouse |
| Subclass | IgG1 kappa |
| Myeloma Used | Sp2/0 |
| Research Area | Cancer, Cell Cycle, Epigenetics & Nuclear Signalling |
References: 10 entries
Screpanti et al. 2011. Curr Biol. 21(5):391-8. PMID: 21353556.
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.
Europe PMC ID: 21353556
Santaguida et al. 2010. J Cell Biol. 190(1):73-87. PMID: 20624901.
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.
Europe PMC ID: 20624901
De Antoni et al. 2005. Curr Biol. 15(3):214-25. PMID: 15694304.
The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.
Europe PMC ID: 15694304
Steensgaard et al. 2004. EMBO Rep. 5(6):626-31. PMID: 15133482.
Sgt1 is required for human kinetochore assembly.
Europe PMC ID: 15133482
DeLuca et al. 2003. Curr Biol. 13(23):2103-9. PMID: 14654001.
Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores.
Europe PMC ID: 14654001
Add a reference
References: 10 entries
Screpanti et al. 2011. Curr Biol. 21(5):391-8. PMID: 21353556.
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.
Santaguida et al. 2010. J Cell Biol. 190(1):73-87. PMID: 20624901.
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.
De Antoni et al. 2005. Curr Biol. 15(3):214-25. PMID: 15694304.
The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.
Steensgaard et al. 2004. EMBO Rep. 5(6):626-31. PMID: 15133482.
Sgt1 is required for human kinetochore assembly.
DeLuca et al. 2003. Curr Biol. 13(23):2103-9. PMID: 14654001.
Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores.
Add a reference
