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Anti-Cmt2 [E29-19-14]

Info

Applications IF IP WB
Antigen/Gene or Protein Targets p31 comet
Relevance CMT2, KIF1B, or kinesin-like protein (Klp) functions as a motor for mitochondrial transport, and has a microtubule plus end-directed motility. The KIF1B beta isoform is abundant in brain, while the alpha isoform is abundant in skeletal muscle. Mutations in the KIF1B gene are the cause of Charcot-Marie-Tooth disease type 2A1, which is a primary peripheral axon neuropathy. The KIF1B beta isoform is down-regulated in sporadic amyotrophic lateral sclerosis (ALS).
Host Mouse
Myeloma Used Sp2/0
Research Area Adhesion, Cell Signaling & Signal Transduction, Cell Structure and Motility, Neurobiology

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