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Anti-CHL1 [BB13.13]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets Cell adhesion molecule with homology to L1CAM
Reactivity Mouse
Relevance CHL1 is an extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. CHL1 plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. CHL1 may play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins and recruits ANK3 to the plasma membrane.
Host Rat
Myeloma Used Sp2/0
Research Area Adhesion, Cell Signaling & Signal Transduction, Neurobiology

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