Anti-ABI1/E3B1 [W8-3]
Invented at IFOM-IEO
- Datasheet
- References (4)
- Inventor Info
Info
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | Abelson interactor 1/Eps8 binding protein 1 |
| Reactivity | Human and Mouse |
| Relevance | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. |
| Host | Mouse |
| Subclass | IgG1 kappa |
| Myeloma Used | Sp2/0 |
| Research Area | Adhesion, Cancer, Cell Signaling & Signal Transduction, Gene Expression, Neurobiology |
References: 4 entries
Innocenti et al. 2004. Nat Cell Biol. 6(4):319-27. PMID: 15048123.
Abi1 is essential for the formation and activation of a WAVE2 signalling complex.
Europe PMC ID: 15048123
Steffen et al. 2004. EMBO J. 23(4):749-59. PMID: 14765121.
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.
Europe PMC ID: 14765121
Add a reference
References: 4 entries
Innocenti et al. 2004. Nat Cell Biol. 6(4):319-27. PMID: 15048123.
Abi1 is essential for the formation and activation of a WAVE2 signalling complex.
Steffen et al. 2004. EMBO J. 23(4):749-59. PMID: 14765121.
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.
Add a reference
