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Anti-ABI1/E3B1 [W8-3]

Info

Applications IF IP WB
Antigen/Gene or Protein Targets Abelson interactor 1/Eps8 binding protein 1
Reactivity Human and Mouse
Relevance May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.
Host Mouse
Subclass IgG1 kappa
Myeloma Used Sp2/0
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction, Gene Expression, Neurobiology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Innocenti et al. 2004. Nat Cell Biol. 6(4):319-27. PMID: 15048123.

Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

Europe PMC ID: 15048123

Steffen et al. 2004. EMBO J. 23(4):749-59. PMID: 14765121.

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.

Europe PMC ID: 14765121


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References: 4 entries

Innocenti et al. 2004. Nat Cell Biol. 6(4):319-27. PMID: 15048123.

Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

Steffen et al. 2004. EMBO J. 23(4):749-59. PMID: 14765121.

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.


Add a reference

Inventor Information

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