Anti-BRCA1 [21A2]
Invented at Icahn School Of Medicine At Mount Sinai
- Datasheet
- References (0)
- Inventor Info
Info
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | BRCA1 |
| Synonyms | BRCA1/BRCA2 containing complex subunit 1, BRCA1/BRCA2-containing complex, subunit 1, IRIS, PNCA4, PPP1R53, Protein phosphatase |
| Reactivity | Human |
| Relevance | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. |
| Host | Mouse |
| Immunogen | Recombinant protein - aa1314-1600 |
| Subclass | Not Known |
| Notes | Antibody also known as "KEN" |
| Research Area | Cancer, Cell Cycle, Drug Discovery & Development, Protein Degradation |
References
There are 0 reference entries for this reagent.
References: 0 entry
There is no reference for this reagent yet, feel free to use the button below to suggest one.
Add a reference
References: 0 entry
There is no reference for this reagent yet, feel free to use the button below to suggest one.
Add a reference
