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Anti-Beta amyloid 1-43 [9C4]

Info

Applications ELISA IHC WB
Antigen/Gene or Protein Targets Beta amyloid 43
Synonyms ABETA, ABPP, AD1, Adap, AICD-50, AICD-57, AICD-59, AID(50), AID(57), AID(59), Alzheimer disease amyloid protein, Amyloid intracellular domain 50, Amyloid intracellular domain 57, Amyloid intracellular domain 59, APP, APPI, Beta amyloid protein 40, Beta APP40, Beta-APP40, Beta-APP42, BetaAPP, C31, Cerebral vascular amyloid peptide
Reactivity Mouse and Human
Relevance Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons.
Host Mouse
Subclass IgG1
Research Area Adhesion, Apoptosis and Programmed Cell Death, Cell Structure and Motility, Neurobiology, Protein Degradation

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