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Anti-Beta amyloid 1-42 [12F4]

Info

Applications ELISA IHC WB
Antigen/Gene or Protein Targets Beta amyloid 42
Synonyms ABETA, ABPP, AD1, Adap, AICD-50, AICD-57, AICD-59, AID(50), AID(57), AID(59), Alzheimer disease amyloid protein, Amyloid intracellular domain 50, Amyloid intracellular domain 57, Amyloid intracellular domain 59, APP, APPI, Beta amyloid protein 40, Beta APP40, Beta-APP40, Beta-APP42, BetaAPP, C31, Cerebral vascular amyloid peptide
Reactivity Mouse and Human
Relevance Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons.
Host Mouse
Subclass IgG1
Research Area Adhesion, Apoptosis and Programmed Cell Death, Cell Structure and Motility, Neurobiology, Protein Degradation

References

There are 4 reference entries for this reagent.

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References: 4 entries

Koronyo-Hamaoui et al. 2011. Neuroimage. 54 Suppl 1:S204-17. PMID: 20550967.

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model.

Europe PMC ID: 20550967

Sudol et al. 2009. Mol Ther. 17(12):2031-40. PMID: 19638957.

Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.

Europe PMC ID: 19638957


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References: 4 entries

Koronyo-Hamaoui et al. 2011. Neuroimage. 54 Suppl 1:S204-17. PMID: 20550967.

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model.

Sudol et al. 2009. Mol Ther. 17(12):2031-40. PMID: 19638957.

Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.


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