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Anti-LRP6 [1c10]

Info

Applications WB
Antigen/Gene or Protein Targets LRP6
Synonyms ADCAD2, C030016K15Rik, Cd, FLJ90062, FLJ90421, Low density lipoprotein receptor related protein 6, Low-density lipoprotein receptor-related protein 6, LRP-6
Reactivity Human and Mouse
Relevance Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
Host Mouse
Subclass IgG1
Research Area Cell Signaling & Signal Transduction, Stem Cell Biology

References

There are 6 reference entries for this reagent.

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References: 6 entries

van Dinther et al. 2013. PLoS One. 8(4):e62295. PMID: 23638027.

Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.

Europe PMC ID: 23638027

Goel et al. 2012. J Biol Chem. 287(20):16454-66. PMID: 22433869.

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

Europe PMC ID: 22433869

Khan et al. 2007. Mol Cell Biol. 27(20):7291-301. PMID: 17698587.

Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.

Europe PMC ID: 17698587


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References: 6 entries

van Dinther et al. 2013. PLoS One. 8(4):e62295. PMID: 23638027.

Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.

Goel et al. 2012. J Biol Chem. 287(20):16454-66. PMID: 22433869.

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

Khan et al. 2007. Mol Cell Biol. 27(20):7291-301. PMID: 17698587.

Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor.


Add a reference

Inventor Information

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