Anti-GluR2 [6C4]
Invented at Icahn School Of Medicine At Mount Sinai
- Datasheet
- References (4)
- Inventor Info
Info
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | GluR2 |
| Synonyms | AMPA 2, AMPA selective glutamate receptor 2, AMPA-selective glutamate receptor 2, AMPA2, GluA2, GLUR 2, GLUR B, GluR K2, GluR-2, GluR-B, GluR-K2, GLUR2, GLURB, Glutamate receptor 2, Glutamate receptor ionotropic AMPA 2, Glutamate receptor ionotropic, Gria2 |
| Reactivity | Mouse, Rat, Primate and Human |
| Relevance | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Host | Mouse |
| Subclass | IgG2a |
| Research Area | Neurobiology |
References: 4 entries
Nagy et al. 2004. J Neurosci. 24(25):5766-77. PMID: 15215299.
Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method.
Europe PMC ID: 15215299
Vissavajjhala et al. 1996. Exp Neurol. 142(2):296-312. PMID: 8934561.
Synaptic distribution of the AMPA-GluR2 subunit and its colocalization with calcium-binding proteins in rat cerebral cortex: an immunohistochemical study using a GluR2-specific monoclonal antibody.
Europe PMC ID: 8934561
Add a reference
References: 4 entries
Nagy et al. 2004. J Neurosci. 24(25):5766-77. PMID: 15215299.
Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method.
Vissavajjhala et al. 1996. Exp Neurol. 142(2):296-312. PMID: 8934561.
Synaptic distribution of the AMPA-GluR2 subunit and its colocalization with calcium-binding proteins in rat cerebral cortex: an immunohistochemical study using a GluR2-specific monoclonal antibody.
Add a reference
