Anti-FANCB [M38P3E10]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human breast cancer tissue sections using Anti-FANCB [M38P3E10]. The antibody shows both nuclear and cytoplasmic staining but it is predominately cytoplasmic.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/d2cf1f19-adbb-48ce-86ba-1467af9c1286.jpg)
![Western blot of Jurkat cell lysates probed with Anti-FANCB [M38P3E10]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/a33fbbc5-3de1-41ab-9b83-662fcde5e545.png)
![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human breast cancer tissue sections using Anti-FANCB [M38P3E10]. The antibody shows both nuclear and cytoplasmic staining but it is predominately cytoplasmic.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/d2cf1f19-adbb-48ce-86ba-1467af9c1286.jpg)
![Western blot of Jurkat cell lysates probed with Anti-FANCB [M38P3E10]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/a33fbbc5-3de1-41ab-9b83-662fcde5e545.png)
![Image thumbnail for Anti-FANCB [M38P3E10]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/d2cf1f19-adbb-48ce-86ba-1467af9c1286.jpg)
![Image thumbnail for Anti-FANCB [M38P3E10]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/a33fbbc5-3de1-41ab-9b83-662fcde5e545.png)
| Catalogue Number | 152796 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Fanconi Anemia, Complementation Group B (FANCB) |
| Synonyms | FA2, FAAP90, FAAP95, FAB, FACB, Fancb, FANCB_HUMAN, Fanconi anemia associated polypeptide of 95 kDa, Fanconi anemia group B protein, Fanconi anemia, complementation group B, Fanconi anemia-associated polypeptide of 95 kDa, Protein FACB |
| Reactivity | Human |
| Relevance | FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide- DRRENIHPYR |
| Positive Control | IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 98 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | For IHC perform antigen retrieval step: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0 |
| Research Area | Cancer, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
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