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Anti-FANCB [M38P3E10]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152796
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Fanconi Anemia, Complementation Group B (FANCB)
Synonyms FA2, FAAP90, FAAP95, FAB, FACB, Fancb, FANCB_HUMAN, Fanconi anemia associated polypeptide of 95 kDa, Fanconi anemia group B protein, Fanconi anemia, complementation group B, Fanconi anemia-associated polypeptide of 95 kDa, Protein FACB
Reactivity Human
Relevance FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide- DRRENIHPYR
Subclass IgG1 kappa
Positive Control IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray
Molecular Weight (kDa) 98
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes For IHC perform antigen retrieval step: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0
Research Area Cancer, DNA Damage and Repair, Epigenetics & Nuclear Signalling

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