Anti-DRAM2 [VAB24-P1C8*A3]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
- Datasheet
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![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human breast cancer tissue using anti-DRAM2 [VAB24-P1C8*A3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/ae93a0ea-7897-4019-a904-f63837454d03.jpg)
![Immunohistochemistry images are showing a strong cytoplasmic positivity of DRAM2 in (A) primary colorectal cancer whilst weak staining is observed in (B) normal colon mucosa, using Anti-DRAM2 [VAB24-P1C8*A3]. IHC was performed on formalin-fixed, paraffin-embedded tissue sections. Antigen retrieval step is required (microwave 10 min @ 950W in 0.01M sodium citrate buffer, pH 6.0).](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/5131c4e2-9150-407d-90fa-d5e320e678d6.png)
![Western blot of Jurkat cell lysates probed with Anti-DRAM2 [VAB24-P1C8*A3].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/60889e0a-913a-41d1-8c4e-6642c4fbcb3e.png)
![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human breast cancer tissue using anti-DRAM2 [VAB24-P1C8*A3]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/ae93a0ea-7897-4019-a904-f63837454d03.jpg)
![Immunohistochemistry images are showing a strong cytoplasmic positivity of DRAM2 in (A) primary colorectal cancer whilst weak staining is observed in (B) normal colon mucosa, using Anti-DRAM2 [VAB24-P1C8*A3]. IHC was performed on formalin-fixed, paraffin-embedded tissue sections. Antigen retrieval step is required (microwave 10 min @ 950W in 0.01M sodium citrate buffer, pH 6.0).](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/5131c4e2-9150-407d-90fa-d5e320e678d6.png)
![Western blot of Jurkat cell lysates probed with Anti-DRAM2 [VAB24-P1C8*A3].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/60889e0a-913a-41d1-8c4e-6642c4fbcb3e.png)
![Image thumbnail for Anti-DRAM2 [VAB24-P1C8*A3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/ae93a0ea-7897-4019-a904-f63837454d03.jpg)
![Image thumbnail for Anti-DRAM2 [VAB24-P1C8*A3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/5131c4e2-9150-407d-90fa-d5e320e678d6.png)
![Image thumbnail for Anti-DRAM2 [VAB24-P1C8*A3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/60889e0a-913a-41d1-8c4e-6642c4fbcb3e.png)
| Catalogue Number | 152793 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | DNA-Damage Regulated Autophagy Modulator 2 (DRAM2) |
| Synonyms | 2010305N14Rik, 2610318G18Rik, AI647667, damage regulated autophagy modulator 2, DNA damage regulated autophagy modulator 2, DNA damage regulated autophagy modulator protein 2, DNA damage-regulated autophagy modulator protein 2, Dram2, DRAM2_HUMAN, PRO180, PSEC0031, RP5-1180E21.1, Tmem77, Transmembrane protein 77, WWFQ154 |
| Reactivity | Human |
| Relevance | DRAM2's expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Not detected in brain or thymus. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide HGLTLYDTAP. Note that peptide immunogen is identical in sheep (Ovis aries), cow (Bos taurus), dog (Canis familiaris), pig (Sus scrofa) and horse (Equus caballus). |
| Positive Control | IHC - formalin-fixed, paraffin-embedded multi tumour tissue microarray |
| Subclass | IgG1 kappa |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | For IHC antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0 |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism |
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