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Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)

Invented by Dr Michael (Mike) Coogan at Lancaster University

Info

Catalogue Number 152786
Type Luminophore
Molecular Formula (ReO3N3CO)3ReAgO
Molecular Weight (g/mol) 1735
Solubility DMSO
Research Area Cancer
Relevance Ag-1 is a luminescent trimeric, rehenium-based molecular vessel which strongly binds silver ions. Ag-1 displays a large Stokes shift (ca. 200nm) which compares very favourably with large Stokes shift materials such as quantum dots. A distinct pattern of localisation has been observed within the nucleus suggesting nucleolar localisation. This could be useful not only for the ability to image nucleoli, but also suggests applications in radiotherapy as Auger electrons emitted by certain isotopes are often considered to be most effective at killing tumour cells when in close proximity to nucleic acids.
Notes Ag-1:
λ max excitation = 371 nm (broad peak extends into the visible and can be excited at 405 nm in microscopy)
λ max emission = 571;
lifetime τ = 21 ns.

Ag-1 does not release Ag+ except under forcing conditions, unlike physiological conditions.

References: 1 entry

Thorp-Greenwood et al. 2011. Chem Commun (Camb). 47(11):3096-8. PMID: 21311811.


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References: 1 entry

Thorp-Greenwood et al. 2011. Chem Commun (Camb). 47(11):3096-8. PMID: 21311811.


Add a reference

References: 1 entry

Thorp-Greenwood et al. 2011. Chem Commun (Camb). 47(11):3096-8. PMID: 21311811.


Add a reference


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