Anti-WNK1 [M42-P3B10]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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![Western blot staining of HeLa cell lysate using anti-WNK1 [M42-P3B10]. A 250kDa protein was detected.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/d404716e-eba2-4d86-9b03-0fb9eb2515e9.png)
![Western blot staining of HeLa cell lysate using anti-WNK1 [M42-P3B10]. A 250kDa protein was detected.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/d404716e-eba2-4d86-9b03-0fb9eb2515e9.png)
![Image thumbnail for Anti-WNK1 [M42-P3B10]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/d404716e-eba2-4d86-9b03-0fb9eb2515e9.png)
| Catalogue Number | 152783 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Serine/threonine-protein kinase WNK1 |
| Synonyms | WNK1, Erythrocyte 65 kDa protein, p65, Kinase deficient protein, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, WNK Lysine Deficient Protein Kinase 1, hWNK1 |
| Reactivity | Human |
| Relevance |
Anti-WNK1 [M42-P3B10] antibody is specific for WNK1 a serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII) [MIM:145260]. PHAII is an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron. Defects in WNK1 are a cause of hereditary sensory and autonomic neuropathy type 2A (HSAN2A) [MIM:201300]. A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2A is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation, onset of symptoms in infancy or early childhood, occurrence of distal extremity pathologies (paronychia, whitlows, ulcers, and Charcot joints), frequent amputations, sensory loss that affects all modalities of sensation (lower and upper limbs and perhaps the trunk as well), absence or diminution of tendon reflexes (usually in all limbs), minimal autonomic dysfunction, absence of sensory nerve action potentials, and virtual absence of myelinated fibers with decreased numbers of unmyelinated fibers in sural nerves. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide KSISNPPGSN-peptide immunogen is identical in mouse (Mus musculus), rat (Rattus norvegicus), sheep (Ovis aries), cow (Bos taurus), dog (Canis familiaris), pig (Sus scrofa), horse (Equus caballus) and chichen (Gallus gallus). |
| Positive Control | HeLa cell lysate |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 250 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | IHC validation - validated on multi-tissue multi-tumour array, specific staining in small population of cells was observed. |
| Research Area | Cell Signaling & Signal Transduction |
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