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Anti-BAG3 [V65P1E8*D2]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152781
Applications ELISA IHC WB
Antigen/Gene or Protein Targets BAG family molecular chaperone regulator 3
Synonyms BAG3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1
Reactivity Human
Relevance Anti-BCL2-Associated Athanogene 3 (BAG3) [V65P1E8*D2] is specific for human BAG3. BAG3 is involved in chaperone-assisted selective autophagy. Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity.

Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide MTDTPGNPAAP
Subclass IgG1 kappa
Myeloma Used P3X63Ag8.653
Strain Balb/c
Research Area Apoptosis and Programmed Cell Death, Cancer, Cardiovascular, Metabolism

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