Anti-HPV18E6 [C1N1]
Invented by Dr Lawrence Banks from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 152765 |
| Applications | ELISA IP WB |
| Antigen/Gene or Protein Targets | Human papillomavirus type 18 (HPV-18) specific epitopes on the E6 polypeptide |
| Synonyms | HPV-18 E6, HPV-18 E6 protein, HPV18 E6, HPV18E6 |
| Reactivity | Virus |
| Relevance | The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies. |
| Host | Mouse |
| Immunogen | HPV18E6-beta-galactosidase fusion protein synthesized in E. coli |
| Positive Control | HPV infected tissue |
| Subclass | IgG |
| Molecular Weight (kDa) | 16.5 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Strain | Balb/c |
| Research Area | Cancer, Virology |
References: 2 entries
Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.
Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.
Europe PMC ID: 3033140
Add a reference
References: 2 entries
Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.
Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.
Add a reference
