Cancer Research Technology
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Catalogue Number 152765
Applications ELISA IP WB
Antigen/Gene or Protein Targets Human papillomavirus type 18 (HPV-18) specific epitopes on the E6 polypeptide
Synonyms HPV-18 E6, HPV-18 E6 protein, HPV18 E6, HPV18E6
Reactivity Virus
Relevance The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
Host Mouse
Immunogen HPV18E6-beta-galactosidase fusion protein synthesized in E. coli
Positive Control HPV infected tissue
Subclass IgG
Molecular Weight (kDa) 16.5
Myeloma Used P3/NS1/1-Ag4.1
Strain Balb/c
Research Area Cancer, Virology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.

Europe PMC ID: 3033140


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References: 2 entries

Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.


Add a reference