Anti-CML28 [V80P1C10*C]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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![Immunohistochemistry was performed on formalin-fixed paraffin-embedded hepatocellular carcinoma tissue sections using anti-CML28 [V80P1C10*C]. Cytoplasmic staining was observed.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/db3a9199-8f92-4b8b-9bee-fdf61c523774.jpg)
![Western blotting was performed on Jurkat cell lysates using anti-CML28 [V80P1C10*C]. A product of approx 28 kDa was detected.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/f5516264-e98b-4707-a5c9-d6e5fb6fd662.png)
![Immunohistochemistry was performed on formalin-fixed paraffin-embedded hepatocellular carcinoma tissue sections using anti-CML28 [V80P1C10*C]. Cytoplasmic staining was observed.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/db3a9199-8f92-4b8b-9bee-fdf61c523774.jpg)
![Western blotting was performed on Jurkat cell lysates using anti-CML28 [V80P1C10*C]. A product of approx 28 kDa was detected.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/f5516264-e98b-4707-a5c9-d6e5fb6fd662.png)
![Image thumbnail for Anti-CML28 [V80P1C10*C]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/db3a9199-8f92-4b8b-9bee-fdf61c523774.jpg)
![Image thumbnail for Anti-CML28 [V80P1C10*C]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/f5516264-e98b-4707-a5c9-d6e5fb6fd662.png)
| Catalogue Number | 152760 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Chronic Myelogenous Leukemia Tumor Antigen 28 (CML28) |
| Synonyms | Exosome complex component RRP46, Exosome component 5, Ribosomal RNA-processing protein 46, p12B, EXOSC5 |
| Reactivity | Human |
| Relevance | CML28 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. |
| Host | Mouse |
| Immunogen | Peptide Sequence – KLLMSSTKGLY |
| Positive Control | Jurkat cell lysate |
| Subclass | IgG |
| Molecular Weight (kDa) | 28 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Research Area | Epigenetics & Nuclear Signalling |
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