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Anti-SLA2 [Z30P1F12*F4]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152758
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Src-Like-Adaptor 2 (SLA2)
Synonyms Modulator of antigen receptor signaling (MARS), Src-like adapter protein 2 (SLAP-2), SLA-2
Reactivity Human
Relevance SLA2 (Src-like-adapter 2), also known as C20orf156 or SLAP2, is a 261 amino acid protein that exists as four alternatively spliced isoforms which localize to either the cytoplasm or to the cell membrane and contain one SH2 domain and one SH3 domain. Expressed predominately in tissues of the immune system, including thymus, spleen and lymph nodes, SLA2 functions as an adaptor protein that negatively regulates T-cell receptor (TCR) signaling and may inhibit T-cell activation. SLA2 interacts with Zap-70 and is subject to posttranslational phosphorylation. The gene encoding SLA2 maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome.
Host Mouse
Immunogen Peptide Sequence – LRESLSFY
Subclass IgG
Positive Control Jurkat cell lysate
Molecular Weight (kDa) 29
Myeloma Used P3X63Ag8.653
Strain Balb/c
Research Area Immunology

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