Anti-SPATA25 [Z37P3H11*B2]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Info
![Immunohistochemistry was performed on formalin-fixed paraffin-embedded oesophageal cancer tissue sections using anti-SPATA25 [Z37P3H11*B2]. Nuclear staining was observed.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/b4b08051-4ed2-4178-bacf-4a0c55d04738.jpg)
![Western blotting was performed on Jurkat cell lysates using anti-SPATA25 [Z37P3H11*B2].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/6165c772-34a7-46db-8958-80e32eaefdd4.jpg)
![Immunohistochemistry images are showing the immunostaining of Anti-SPATA25 [Z37P3H11*B2] in normal colon mucosa and primary colorectal tumour. A variation of immunostaining intensity and localisation between cases is observed. (A) Normal colon, (B) Primary colorectal cancer - cytoplasmic staining, (C) Primary colorectal cancer - nuclear staining. IHC was performed on formalin-fixed, paraffin-embedded tissue sections. Antigen retrieval step was required (microwave 10 min @ 950W in 0.01M sodium citrate buffer, pH 6.0).](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/28173107-5abd-4590-96c8-c4cec83a80fd.png)
![Immunohistochemistry was performed on formalin-fixed paraffin-embedded oesophageal cancer tissue sections using anti-SPATA25 [Z37P3H11*B2]. Nuclear staining was observed.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/b4b08051-4ed2-4178-bacf-4a0c55d04738.jpg)
![Western blotting was performed on Jurkat cell lysates using anti-SPATA25 [Z37P3H11*B2].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/6165c772-34a7-46db-8958-80e32eaefdd4.jpg)
![Immunohistochemistry images are showing the immunostaining of Anti-SPATA25 [Z37P3H11*B2] in normal colon mucosa and primary colorectal tumour. A variation of immunostaining intensity and localisation between cases is observed. (A) Normal colon, (B) Primary colorectal cancer - cytoplasmic staining, (C) Primary colorectal cancer - nuclear staining. IHC was performed on formalin-fixed, paraffin-embedded tissue sections. Antigen retrieval step was required (microwave 10 min @ 950W in 0.01M sodium citrate buffer, pH 6.0).](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/28173107-5abd-4590-96c8-c4cec83a80fd.png)
![Image thumbnail for Anti-SPATA25 [Z37P3H11*B2]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/b4b08051-4ed2-4178-bacf-4a0c55d04738.jpg)
![Image thumbnail for Anti-SPATA25 [Z37P3H11*B2]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/6165c772-34a7-46db-8958-80e32eaefdd4.jpg)
![Image thumbnail for Anti-SPATA25 [Z37P3H11*B2]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/28173107-5abd-4590-96c8-c4cec83a80fd.png)
| Catalogue Number | 152757 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Spermatogenesis Associated 25 (SPATA25) |
| Synonyms | Testis-specific gene 23 protein |
| Reactivity | Human |
| Relevance | SPATA25 (spermatogenesis-associated protein 25), also known as TSG23 (testis-specific gene 23 protein), is a 227 amino acid single-pass membrane protein that is thought to play a role in spermatogenesis. Predominantly expressed in testis, SPATA25 is found at 60-fold higher levels in adult testis than fetal testis. The gene encoding SPATA25 maps to human chromosome 20q13.12 and mouse chromosome 2 H3. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought to be important for seminal production and may be potential targets for male contraception. |
| Host | Mouse |
| Immunogen | Peptide Sequence – LVRSKRGQP |
| Positive Control | Jurkat cell lysate |
| Subclass | IgG |
| Molecular Weight (kDa) | 23 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Research Area | Developmental Biology |
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