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Anti-WSB1 [K5P2H10*E10]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152738
Applications ELISA IHC WB
Antigen/Gene or Protein Targets WD repeat and SOCS box containing 1, WSB-1
Reactivity Human
Relevance WSB1 is a member of the WD-protein subfamily. It shares a high sequence identity to mouse and chick proteins. It contains six WD-repeats spanning most of the protein and an SOCS box in the C-terminus. It is a probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes type II iodothyronine deiodinase/DIO2. There are two named isoforms.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide RRVMPTQEVQE
Positive Control Jurkat cell lysates
Subclass IgG1 kappa
Molecular Weight (kDa) 49
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Peptide immunogen is identical in sequence to mouse (Mus musculus), rat (Rattus norvegicus), sheep (Ovis aries), cow (Bos taurus), dog (Canis familiaris), pig (Sus scrofa) and horse (Equus caballus).
Research Area Epigenetics & Nuclear Signalling, Protein Degradation

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