Anti-WSB1 [K5P2H10*E10]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Info
![Western blot on Jurkat cell lysate using anti-WSB1 [K5P6A5].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/dfa27124-4b00-40e1-a0f8-62890e0fa191.jpg)
![Immunohistochemistry using Anti-WSB1 [K5P2H10*E10]. (A) Cytoplasmic immunoreactivity of glandular epithelium and lamina propria cells in normal human colon. Strong staining is observed in plasma cells of the lamina propria. (B) Strong cytoplasmic immunoreactivity in primary colorectal cancer. IHC was performed on formalin-fixed, paraffin-embedded tissue sections. Antigen retrieval step is required using EDTA buffer (pH8).](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/3cd24b0e-c75e-4dd3-9348-9cf9c189d79d.png)
![Survival curve comparing patients outcome categorised by expression of WSB1 using Anti-WSB1 [K5P2H10*E10]. Positive expression of WSB1 was associated with improved patients’ outcome in MMR defective colorectal cancer tumours (p=0.015). The peptide immunogen used to generate the antibody is identical in mouse (Mus musculus), rat (Rattus norvegicus), sheep (Ovis aries), bovine (Bos taurus), dog (Canis familiaris) and horse (Equus caballus).](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/fe31a4b2-fd07-4d33-a9c5-c5e8d02b62b8.png)
![Western blot on Jurkat cell lysate using anti-WSB1 [K5P6A5].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/dfa27124-4b00-40e1-a0f8-62890e0fa191.jpg)
![Immunohistochemistry using Anti-WSB1 [K5P2H10*E10]. (A) Cytoplasmic immunoreactivity of glandular epithelium and lamina propria cells in normal human colon. Strong staining is observed in plasma cells of the lamina propria. (B) Strong cytoplasmic immunoreactivity in primary colorectal cancer. IHC was performed on formalin-fixed, paraffin-embedded tissue sections. Antigen retrieval step is required using EDTA buffer (pH8).](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/3cd24b0e-c75e-4dd3-9348-9cf9c189d79d.png)
![Survival curve comparing patients outcome categorised by expression of WSB1 using Anti-WSB1 [K5P2H10*E10]. Positive expression of WSB1 was associated with improved patients’ outcome in MMR defective colorectal cancer tumours (p=0.015). The peptide immunogen used to generate the antibody is identical in mouse (Mus musculus), rat (Rattus norvegicus), sheep (Ovis aries), bovine (Bos taurus), dog (Canis familiaris) and horse (Equus caballus).](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/fe31a4b2-fd07-4d33-a9c5-c5e8d02b62b8.png)
![Image thumbnail for Anti-WSB1 [K5P2H10*E10]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/dfa27124-4b00-40e1-a0f8-62890e0fa191.jpg)
![Image thumbnail for Anti-WSB1 [K5P2H10*E10]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/3cd24b0e-c75e-4dd3-9348-9cf9c189d79d.png)
![Image thumbnail for Anti-WSB1 [K5P2H10*E10]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/fe31a4b2-fd07-4d33-a9c5-c5e8d02b62b8.png)
| Catalogue Number | 152738 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | WD repeat and SOCS box containing 1, WSB-1 |
| Reactivity | Human |
| Relevance | WSB1 is a member of the WD-protein subfamily. It shares a high sequence identity to mouse and chick proteins. It contains six WD-repeats spanning most of the protein and an SOCS box in the C-terminus. It is a probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes type II iodothyronine deiodinase/DIO2. There are two named isoforms. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide RRVMPTQEVQE |
| Positive Control | Jurkat cell lysates |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 49 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | Peptide immunogen is identical in sequence to mouse (Mus musculus), rat (Rattus norvegicus), sheep (Ovis aries), cow (Bos taurus), dog (Canis familiaris), pig (Sus scrofa) and horse (Equus caballus). |
| Research Area | Epigenetics & Nuclear Signalling, Protein Degradation |
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